To quote this article from Eurogamer :
The best thing about it is the fact that everything, from excisions to defibrillation to draining and twisting and grabbing and stitching and lasering, is done with your hands. [...] You grab hold of things between finger and thumb, physically twist shards of bone around and fit them back into place with your right hand, pull things out of patients by moving your hand away from the screen and actually place defibrillator pads onto patients chests, squeezing both triggers to release the charge. This is as close to actual surgery as any game would ever want to be, and it is a completely unique experience. If you fail an operation, it's your fault. You weren't fast or accurate or clever enough to outwit the virus.
It's a very demanding game that will last you a long time, thanks to its difficulty and varied missions.
Here's a video preview :
